The behavior of cancer in the human body, and the impact it has on other normal and immune cells, can be explained by numerous phenomena. One way our team studies cancer’s behavior is through mathematical frameworks like game theory. We were featured on the cover of PLoS Computational Biology after elucidating novel behavior among cancer clones that drives resistance

Cell metabolism can affect the growth of cancer as well as it’s likelihood of developing drug resistance. Importantly, cell metabolism in immune cells can influence tumor immunogenicity. The Goldman DRG explores multiple aspects of metabolism in the tumor ecosystem. A recent article in Science Signaling we describe a novel metabolic phenotype that cancer cells induce while under drug pressure

Cell therapies are emerging as powerful tools in our anticancer arsenal. The Goldman DRG deploys interdisciplinary science including bioengineering and nanotechnology to design novel drugs that boost the activity of cell therapies in aggressive cancers. In two recent articles in Cancer Research and Front. Mol. Bio. we describe ways to overcome deficits of NK cell adoptive therapy by modulating tumor antigen expression and inactivating environmental factors