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A complete understanding of therapy resistance requires functional interrogation of the biological ecosystem using interdisciplinary science.

 

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Our team is dedicated to unmasking the mechanisms that drive response and resistance to conventional and immuno-modulatory drugs for multiple diseases including cancer and neuro-psychiatry. Importantly, we also seek to provide immediate solutions in the clinic.

Our research lies at the forefront of innovation, integrating a unique interdisciplinary tool set including biology, mathematics, next-generation sequencing and bioengineering approaches. We also place a special emphasis on building an academic, integrated atmosphere culturing our future generation of successful scientists.

RESEARCH HIGHLIGHTS

RESISTANCE AND GAME THEORY

RESISTANCE AND GAME THEORY

The behavior of cancer in the human body, and the impact it has on other normal and immune cells, can be explained by numerous phenomena. One way our team studies cancer’s behavior is through mathematical frameworks like game theory. We were featured on the cover of PLoS Computational Biology after elucidating novel behavior among cancer clones that drives resistance

 

 

 

 

 

 

CELL THERAPY RESPONSE AND RESISTANCE

CELL THERAPY RESPONSE AND RESISTANCE

Cell therapies are emerging as powerful tools in our anticancer arsenal. The Goldman DRG deploys interdisciplinary science including bioengineering and nanotechnology to design novel drugs that boost the activity of cell therapies in aggressive cancers. In two recent articles in Cancer Research and Front. Mol. Bio. we describe ways to overcome deficits of NK cell adoptive therapy by modulating tumor antigen expression and inactivating environmental factors

 

 

 

 

 

 

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